Taking a GLP-1? These Multivitamins Can Help You Fill the Gaps in Your Diet

However, these medications also reduce your appetite and the amount of food you eat, according to Brittany Brown, RD, a registered dietitian in Nova Scotia, Canada. She explains that this can make it difficult to meet your overall nutrient needs. A good multivitamin can help fill nutritional gaps that can arise from eating less, though it’s still important to focus on whole, nutrient-dense foods for optimal health. “Multivitamins should be viewed as an insurance policy rather than a replacement for food,” Brown explains. “They can help fill nutritional gaps, but they cannot replace the benefits of whole foods.”

The best multivitamins for GLP-1 support contain nutrients that may be difficult to get enough of when your appetite is low. “Adequate vitamin D and B vitamins are particularly helpful,” Brown says. Choosing reputable brands or products that have been third-party tested for quality is also important. According to Kay Lee, RDN, CDCES, a Fresno, California–based registered dietitian and diabetes educator, it’s also important to look for an affordable option that you’ll use consistently.

Based on my research and the advice of the experts I spoke with, I’ve assembled this list of the best multivitamins for GLP-1 support. It includes budget-friendly options, different vitamin forms such as gummies, and picks for specific health concerns such as fertility and digestive health. Here are the best multivitamins for GLP-1 support, according to registered dietitians.

• Best with iron: Celebrate META Multi GLP-1 Nutrition Support
• Best budget-friendly: Centrum Nutrient Replenish Multivitamin for GLP-1 Users
• Best daily supplement pack: Nature Made GLP-1 Companion Health Pack
• Best for fertility: FullWell Women’s Nutritional Support for GLP-1 Users
• Best with omega-3: Ritual Women’s Multivitamin 18+
• Best gummy: Vitafusion GLP-1 Support Vitamin and Mineral Blend
• Best for gut health: Replenza Daily Nutritional Supplement
• Best once daily: Pure Encapsulations O.N.E. Multivitamin

To choose the best multivitamins for GLP-1 support, I first spoke with several registered dietitians who work with clients taking GLP-1 medications for weight loss or diabetes management:

• Kay Lee, RDN, CDCES
• Brittany Brown, RD
• Juliana Vocca, RD

These dietitians shared the most important nutritional considerations for people taking GLP-1s and which nutrients may be most important for them to supplement. They also provided advice on choosing a multivitamin brand and specifically recommended multivitamins that were third-party tested for quality and didn’t contain abnormally high levels of any nutrients.

Based on the information they provided and my own research into GLP-1 medications and nutritional concerns, I narrowed down a list of options from reputable brands, brands that I’ve personally tested and trust, brands and products that are highly recommended by dietitians, and products that were designed specifically for people taking GLP-1 medications.

Ready to buy? Here are a few important things to consider as you shop for multivitamins for GLP-1 support.

• Third-Party Testing The U.S. Food and Drug Administration doesn’t require testing of supplements before they can be sold, so third-party testing offers a way to ensure quality.

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  “Independent testing helps ensure the supplement contains what the label states, and reduces the risk of contaminants, which improves overall safety and quality,” Brown says.
• Reasonable Quantities of Nutrients Many multivitamins contain extremely large quantities of vitamins. These megadoses often aren’t necessary, and in some cases could even be dangerous if they exceed the tolerable upper intake level.

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   While it’s normal to see high-dose B vitamins in supplements, it’s best to avoid multivitamins that contain other vitamins or minerals in excess of your daily needs.
• Affordability If you’ll be taking a multivitamin for a while, you’ll need to pick one that’s a good fit for your budget. Fortunately, there are great options at every price level. Centrum and Nature Made, for example, are typically very affordable.
• Ease of Use The best multivitamin is one that you’ll take consistently. For some people, that may mean choosing a liquid or gummy formulation, rather than a pill. It could also mean choosing a once-daily formulation, rather than a multivitamin that requires two or more pills per day.

Proper nutrition is extremely important for people taking GLP-1 medications. Here are some of the major concerns that can be optimized through a healthy diet or supplement use:

• Diet Quality Because you’re eating less on a GLP-1, it’s important to prioritize nutrient density. “You should aim to build meals around high-quality protein, fiber-rich carbohydrates, and healthy fats whenever possible,” Brown says.
• Side Effect Management GLP-1s may cause digestive side effects like nausea, vomiting, or constipation. “Consuming small, frequent meals and limiting high-fat, fried, or greasy foods can help reduce these side effects,” Vocca says.
• Hydration You may also feel less thirsty on a GLP-1, according to Lee. She emphasizes the importance of drinking plenty of fluids to stay well hydrated.
• Micronutrient Intake It can be difficult to get enough vitamins and minerals when your appetite is significantly reduced on a GLP-1. All of the experts we spoke with agree that a multivitamin can be a helpful addition to help fill nutrient gaps, but it’s still important to eat a balanced, varied diet.
• Muscle Loss Quick weight loss can also result in a loss of muscle mass, according to Vocca. This can be counteracted with adequate protein intake and resistance exercises like weight lifting or body-weight training.

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• Vitamin D Vitamin D was the most common nutrient deficiency noted in GLP-1 users. “This is a nutrient I monitor very closely,” Brown notes, “especially when overall intake is reduced.”
• Iron Roughly 60 percent of GLP-1 users in this study didn't consume enough iron.
• Calcium Likewise, 60 percent of GLP-1 users didn’t consume the recommended amount of calcium each day.
• B Vitamins In this study, researchers noted that thiamin (vitamin B1) and vitamin B12 levels tended to decline over time with continued GLP-1 therapy.

Note that not every multivitamin contains all of these nutrients. Some formulas exclude iron (often by design), and calcium is frequently omitted or included in smaller amounts. B vitamins can also vary by formula — for example, a product may include B12 but not thiamin (B1) — so it’s important to review labels carefully and choose a supplement that aligns with your individual needs.