10 Best Doctor-Recommended Pain-Relief Creams of 2026

10 Best Pain Relief Creams, According to Doctors

Sore shoulder? Achy knee? If ice or hot packs don’t seem to be helping, an over-the-counter topical pain-relief cream can offer more serious soothing power.

“When used after proper evaluation, they can be effective in various chronic pain conditions, not just limited to back pain or arthritis,” says Vivek Mehta, MD, a pain management physician at Texas Health Arlington Memorial Hospital in Arlington, Texas. “In many situations, they have excellent tolerability because of low systemic absorption of drugs and usually a low incidence of side effects.”

But with so many options to choose from, it can be tough to tell whether a cream in question will give you the relief you need. We spoke with a pain management specialist and a physical therapist to round up the best pain-relief creams.

Our Top Picks for Pain Relief Cream

When to Consult Your Doctor

Over-the-counter pain relief creams are generally considered safe, though most topicals are designed to be used for no more than a week at a time. You should stop using a cream if you notice redness, a rash, itching, or other signs of irritation. Stick with products that contain ingredients that have been shown to be both safe and effective, Dr. Mehta recommends. Let your provider know if a topical isn’t helping or if the pain gets worse.

pain relief cream

Best Numbing

BenGay Ultra Strength Pain Relief Cream

Pros

  • Numbs pain with menthol, camphor, methyl salicylate
  • Fast-acting
  • Nongreasy cream
  • Flexible spending account (FSA)/health savings account (HSA) eligible

Cons

  • Strong fragrance
  • Sensation may feel too intense for some

Key Specs

  • Active ingredients: Menthol (10 percent), camphor (4 percent), methyl salicylate (30 percent)
  • Application: Three to four times daily
  • Cold or hot relief: Cold

Minor aches and pains or the occasional sprain or strain respond to creams like BenGay, which contains a local anesthetic plus a soothing agent, says Medhat Mikhael, MD, a double board-certified physician specializing in anesthesiology and pain medicine, and medical director at MemorialCare Orange Coast Medical Center in Fountain Valley, California.

“It has an analgesic effect with cold and a vasodilating effect with heat that improves healing and blood supply to the area, with an added local anesthetic to numb the area,” says Dr. Mikhael. The formulation is also nongreasy and won’t leave stains on clothing.

Best for Back Pain

Aspercreme Original Pain Relief Cream

$6.25 at Amazon
$6.58Now 5% Off

Pros

  • Contains trolamine salicylate to help numb aches
  • Fragrance-free
  • Made with aloe
  • FSA/HSA eligible

Cons

  • Should not be used with other topical pain relievers
  • Slightly greasy

Key Specs

  • Active ingredients: Trolamine salicylate
  • Application: Three to four times daily
  • Cold or hot relief: Neither

If you suffer from back pain, you know that a strongly scented formula can be overwhelming when applied to a large area of the body like the back. This cream effectively relieves minor pains and is fragrance-free. “Topical formulations are made with a base and active ingredient, which can be optimized for a particular site on the body,” says Mehta.

This one uses trolamine salicylate, a pain reliever related to aspirin that can help numb minor aches and soreness, including back soreness.

The addition of aloe makes for an extra-soothing feel.

Best for Joint Pain

Voltaren Arthritis Pain Relief Gel

$11.38 at Amazon
$11.98Now 5% Off

Pros

  • Contains 1 percent diclofenac for arthritis pain
  • Nongreasy gel
  • Easy-to-open twist cap
  • FSA/HSA eligible 

Cons

  • May take up to seven days for relief
  • Should not be used on more than two areas at the same time

Key Specs

  • Active ingredients: Diclofenac (1 percent)
  • Application: Four times daily
  • Cold or hot relief: Neither
For joint pain due to osteoarthritis, Mikhael prefers creams containing diclofenac, such as this gel from Voltaren, which is formulated specifically for arthritis pain relief.

The nonsteroidal anti-inflammatory drug (NSAID) has been shown to be as effective as oral NSAIDs at relieving arthritis pain and stiffness, with fewer risks and side effects.

In the past, Voltaren was only available by prescription. But now a version containing 1 percent diclofenac is available over the counter. The gel formulation isn’t greasy, and the twist cap is designed to be easy to open with sore, stiff hands and wrists.
pain relief creams

Best for Shingles

Zostrix Natural Pain Relief Cream

Pros

  • Contains capsaicin to relieve burning sensation from shingles
  • Fragrance-free
  • Nongreasy

Cons

  • Warming sensation may feel too intense for some
  • Not widely available

Key Specs

  • Active ingredients: Capsaicin (0.1 percent)
  • Application: Three to four times daily
  • Cold or hot relief: Hot
Capsaicin-based creams are a good option for easing the shooting, burning pain near the surface of your skin that can strike during or after a shingles infection, says Mikhael. The ingredient, which is derived from chili peppers, is thought to make nerves less sensitive to pain messages.

With 0.1 percent capsaicin to deliver warm, penetrative relief, Zostrix fits the bill. The nongreasy formula feels good on skin, won’t stain clothes, and, because it’s fragrance-free, is less likely to cause irritation.
pain relief cream

Best Cold Therapy

Biofreeze Pain Relief Cream

Pros

  • Contains 10 percent fast-acting cooling menthol
  • Nongreasy cream
  • Includes moisturizing ingredients
  • HSA/FSA eligible

Cons

  • Strong smell
  • Doesn’t contain anti-inflammatory ingredients

Key Specs

  • Active ingredients: Menthol (10 percent)
  • Application: Three to four times daily
  • Cold or hot relief: Cold
Topicals like Biofreeze, which feel cold on the skin, can have an instant pain-relieving effect, Mikhael says. The nongreasy, NSAID-free pain cream contains menthol, which relieves discomfort by desensitizing nerves and reducing blood flow to sore or injured areas. And chances are, it’ll be more soothing than a bag of frozen peas. A 2012 study found that menthol is more effective at easing muscle soreness and discomfort than simply icing the area.


Best Hot Therapy

Sombra Warm Pain Relief

$13.77 at Amazon
$14.49Now 5% Off

Pros

  • Provides gentle pain-relieving warmth
  • Works rapidly
  • Uses natural ingredients such as aloe vera, green tea
  • Free from fragrances, dyes, wax, petroleum, alcohol

Cons

  • Fragrance may not appeal to all
  • Doesn’t contain anti-inflammatory ingredients

Key Specs

  • Active ingredients: Camphor (3 percent), menthol (3 percent)
  • Application: Three to four times daily
  • Cold or hot relief: Both

This formula uses warming camphor combined with other natural ingredients such as aloe vera, green tea, witch hazel, and other plant extracts to provide gentle comfort and relief. There are no artificial colors or fragrances used in the formulation, nor any wax, petroleum, or alcohol. A soothing, warming sensation builds up a few minutes after applying — this isn’t a warming rub that burns. It’s a multitasker designed to work for everything from post-exercise soreness to arthritis. Just be sure to wash your hands well after applying it, so that you don’t accidentally rub it in your eyes — you’ll definitely feel it if you do.

Best Hot-Cold Therapy

Icy Hot With Lidocaine Cream Pain Relief

$6.22 at Amazon
$8.69Now 28% Off

Pros

  • Provides both hot and cold pain relief
  • Works on contact
  • 1 percent menthol, 4 percent lidocaine
  • Nongreasy cream

Cons

  • Should not be used with other topical pain relievers
  • Sensation may feel intense for some

Key Specs

  • Active ingredients: Menthol (1 percent), lidocaine (4 percent)
  • Application: Three to four times daily
  • Cold or hot relief: Both
Some people find that alternating hot and cold therapy delivers more comfort than using either alone. If you’re among them, this cream is for you. This cream does double duty, delivering hot and cold therapy to soothe and numb away pain. It uses menthol to deliver a cooling sensation, plus the numbing agent lidocaine, which temporarily stops nerves from sending pain signals.

“Icy Hot’s particularly popular for backaches and arthritis-related pain, but it’s an all-purpose cream that you can use to relieve neck pain, knee pain, and everywhere in between,” says David Asselin, DPT, a physical therapist practicing in Grand Rapids, Michigan. The nongreasy formula doesn’t feel slick either.

pain relief cream

Best Ointment

Tiger Balm Red Extra Strength Pain Relieving Ointment

Pros

  • Contains camphor and menthol for cooling pain relief
  • Works fast
  • HSA/FSA eligible

Cons

  • Doesn’t contain anti-inflammatory ingredients
  • Strong smell

Key Specs

  • Active ingredients: Camphor (25 percent), menthol (10 percent)
  • Application: Three to four times daily
  • Cold or hot relief: Cooling

This balm will deliver temporary pain relief without breaking the bank. The classic Tiger Balm ointment uses a combo of camphor and menthol to create a cooling sensation that temporarily blocks feelings of discomfort. Because the ingredients merely mask pain, the balm isn’t likely to be as effective as options that also contain anti-inflammatory agents, such as lidocaine or diclofenac. But it’ll get the job done if you’re looking for fast, inexpensive, temporary relief.

pain relief cream

Best Homeopathic

Penetrex Joint & Muscle Care

Pros

  • Contains arnica for homeopathic pain relief
  • Can be used with heating pads and ice packs
  • Lasts up to six to eight hours
  • Nongreasy cream

Cons

  • Homeopathic remedies are studied less than conventional ones
  • More expensive than other options 

Key Specs

  • Active ingredients: Arnica, methylsulfonylmethane, vitamin B6
  • Application: Three to four times daily
  • Cold or hot relief: Neither
This popular cream gets its pain-fighting power from arnica, a homeopathic remedy that may help ease muscle and joint discomfort, particularly back pain.

It also contains methylsulfonylmethane, which is a naturally occurring compound that may help reduce inflammation.

Keep in mind that homeopathic remedies aren’t subjected to the same scientific scrutiny as conventional pain relievers. But this cream might be worth a try if you’re looking for a more natural option, as long as you get the green light from your doctor first.

Best for Massages

Free-Up Professional Massage Cream

$33.29 at Amazon
$36.99Now 10% Off

Pros

  • Slow absorption rate ideal for massage
  • Nongreasy cream
  • Fragrance-free

Cons

  • Doesn’t contain pain-relief ingredients
  • Not widely available

Key Specs

  • Active ingredients: N/A
  • Application: N/A
  • Cold or hot relief: Neither

This smooth, nongreasy lubricant doesn’t contain any active pain-relieving ingredients. Instead, it’s designed to act as a friction-reducer for massages — another tactic for soothing tight, overworked muscles. While it doesn’t contain active pain-fighting ingredients, it can increase the comfort of a massage meant to deliver pain relief to your muscles.

Use the hypoallergenic, fragrance-free cream on your hands to get a deeper rub on areas like your knees, feet, or wrists, or hand the jar to your partner or a friend for help with your back, shoulders, or neck.

Comparison Table

Superlative
Active Ingredients
Application
Cold or hot relief

Best numbing
Menthol, camphor, methyl salicylate
3 to 4 times daily
Cold

Best for back pain
Trolamine salicylate
3 to 4 times daily
Neither
Best for joint pain
Diclofenac
4 times daily
Neither
Best for shingles
Capsaicin
3 to 4 times daily
Hot
Best cold therapy
Menthol
3 to 4 times daily
Cold
Best hot therapy
Camphor, menthol 
3 to 4 times daily
Both
Best hot-cold therapy
Menthol, lidocaine
3 to 4 times daily
Both
Best ointment
Camphor, menthol
3 to 4 times daily
Cold
Best homeopathic
Arnica, methylsulfonylmethane, vitamin B6
3 to 4 times daily
Neither

What to Look for in a Pain-Relief Cream

With so many options out there, it can be tough to know which jar or tube will give you the most bang for your buck. Here are some things to consider that can help you zero in on the best pain-relief cream for you.

  • Active Ingredients Topicals containing NSAIDs like lidocaine or diclofenac work by reducing inflammation, which can help address the root of your discomfort. Other ingredients work by delivering a soothing cooling sensation (menthol, camphor) or a warming feeling (capsaicin). All of these ingredients can be effective for helping you manage your pain, depending on the type of relief you're looking for.


  • Delivery Method Creams, sprays and patches all relieve pain via the same active ingredients, but certain delivery methods might work better on different parts of the body. Creams and gels are best for areas that move a lot, like your hands, elbows, or knees. Patches, on the other hand, will stay put and deliver steady pain relief to places like your back, neck, or shoulders. Looking for something that’s less messy to apply? Try a spray.
  • Combination Treatments Sometimes a pain cream or gel is all you need. But if that’s not cutting it, ask your provider about ways to make your topical work harder. “A combination of topicals and systemic medications like acetaminophen or NSAIDs can be effective for acute pain,” says Mikhael.

How Do Pain-Relief Creams Actually Work?

Topical medications, such as creams, gels, patches, and sprays, are absorbed through your skin. Some rely on active ingredients such as NSAIDs or lidocaine to reduce inflammation and promote healing.

Others use agents such as capsaicin, menthol, or menthol salicylate to create a warming or cooling sensation that can help distract you from the pain.

Cooling agents can also reduce blood flow to a painful area, while warming agents can help dilate blood vessels and encourage more blood flow — two things that can also help promote healing, Mikhael says.
Topicals tend to do a good job at helping people bounce back from acute pain near the surface of the skin — like post-workout soreness in your knees or a pulled neck muscle from sleeping the wrong way. While they can sometimes be helpful for managing chronic discomfort, such as arthritis or chronic low back pain, they’re rarely able to eliminate the pain completely.

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Catherine Brown

Author

Catherine began a career based on health while working at an orthodontist's office, then became a certified yoga and meditation teacher, but soon recognized a call to follow a path in natural wellness through plants.

She is an herbologist who has worked with plant medicine for over two decades. She specializes in Andean and Amazonian medicine from South America. She has consulted for Colombia University and the New York Psychiatric Institution in their studies on plant medicine for mental health.

She is a Reiki master and has been recently exploring the world of sound healing.

Marygrace Taylor

Marygrace Taylor

Author

Marygrace Taylor is an award-winning freelance health and wellness writer with more than 15 years of experience covering topics including women’s health, nutrition, chronic conditions, and preventive medicine. Her work has appeared in top national outlets like Prevention, Parade, Women’s Health, and O, The Oprah Magazine.

She's also the coauthor of three books: Eat Clean, Stay Lean: The Diet, Prevention Mediterranean Table, and Allergy-Friendly Food for Families. She lives in Philadelphia.

Allison M

Allison M. Fout, PA-C

Medical Reviewer

Allison M. Fout, PA-C, has 20 years of experience as a Physician Assistant with a career rooted in orthopedic care. Since 2015, she has been a provider at Excelsior Orthopaedics in Buffalo, New York, specializing in sports medicine, joint replacements, fracture care, and a wide range of musculoskeletal conditions.

She works with patients across multiple age groups — from young athletes to aging adults — helping them recover function, reduce pain, and return to the activities they enjoy.

Her dedication to patient-centered care earns the trust of both her patients and colleagues. Beyond the clinic and operating room, she's involved in education and mentorship. She serves as a mentor to fellow clinicians and students alike and works as an adjunct instructor of orthopedics for the PA program at Daemen University, guiding and empowering the next generation of healthcare professionals as they develop their technical skills, knowledge, and confidence.

Orlando de Guzman

Fact-Checker

Orlando de Guzman is a writer and editor with expertise in health and environmental news. He has a background in investigative and science journalism and has worked on documentary films about war and trauma, health, sanitation, and the changing climate around the world. His interest in health and medicine started after an early career as a medical and legal translator.

De Guzman is a longtime health and fitness enthusiast who is interested in nutrition, diet, and mental health. He participates in endurance sports and cross-trains in several traditions of martial arts from Southeast Asia. De Guzman is interested in how the progressively complex movements of martial arts training can improve cognition and mental well-being, especially for those with PTSD and for those approaching middle age and beyond.

De Guzman has a dual B.A. in communications and international studies from the University of Washington in Seattle. He is committed to factual storytelling and evidence-based reporting on critical choices that affect our planet.

Lili Ladaga

Lili Ladaga

Editor
Lili Ladaga is a freelance editor on the Marketplace Team at Everyday Health.
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