Essential Facts About Iron-Deficiency Anemia and Your Heart

Essential Facts About Iron-Deficiency Anemia and Your Heart

Essential Facts About Iron-Deficiency Anemia and Your Heart
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If you have a health condition that affects your heart, such as high blood pressure, diabetes, coronary artery disease, or heart failure, then it’s important to be aware of another condition that can affect your heart health: iron-deficiency anemia.

Iron-deficiency anemia develops when the body doesn’t have enough iron to adequately produce red blood cells, which are responsible for transporting oxygen throughout the body. While it’s especially common among women of reproductive age, other groups may also be at risk for the condition, including older adults.

 Recent evidence suggests that iron-deficiency anemia may also be more common than previously believed in adults with heart conditions.

While iron-deficiency anemia can worsen or even cause heart conditions, any damage can usually be reversed if the anemia is detected and treated early enough.

 Here’s what you should know about iron-deficiency anemia and its impact on heart health.

Iron-Deficiency Anemia Symptoms Vary

The symptoms of iron-deficiency anemia are caused by inadequate oxygen in the body’s tissues, says Daniel A. Landau, MD, a hematologist and oncologist at Medical University of South Carolina in Charleston. “It’s an issue of supply and demand,” he says, adding that fatigue is the most common symptom, reported by about 90 percent of people that he sees with the condition.

Other common symptoms, Dr. Landau says, include dizziness or fainting and lack of mental sharpness. In some cases, people experience the urge to eat unusual things, like dirt or chalk. This is a condition known as pica.

But Landau emphasizes that iron deficiency isn’t usually an isolated condition. “We don’t normally become iron-deficient just because we’re not eating the right diet,” he says. “Normally, it’s because of blood loss or some other issue” that may require urgent treatment, such as gastrointestinal bleeding or even colon cancer.

Mild anemia cases may not cause any overt symptoms at all.

Iron Deficiency Anemia and Heart Health

“I think the link between iron deficiency and heart health was very poorly understood until recently,” says Landau. But studies in recent years have shed some light on this relationship.

Research suggests iron deficiency is seen in about 50 percent of people with heart failure and up to 60 percent of people with coronary artery disease.

In cases of severe anemia, the heart tends to compensate for the lack of red blood cells reaching the body’s tissues by pumping faster. Over time, this can lead to heart failure, in which the heart can no longer pump enough blood to meet the body’s needs.

 Symptoms of heart failure can include fluid retention, shortness of breath, weakness, and very low blood pressure.

Iron-Deficiency Anemia Screening and Treatment

If you’re experiencing any of the symptoms associated with iron-deficiency anemia, it’s crucial to see your doctor to find out what’s going on.

“The first screening test is just to figure out whether you are anemic or not,” says Landau. This will look to see if you’re lacking adequate red blood cells. If you are anemic, your doctor will try to establish whether it’s due to iron deficiency or some other cause, like a vitamin deficiency, underlying chronic inflammation, kidney disease, or poor thyroid function. Possible loss of blood from your gastrointestinal tract may also be investigated.

If you’re found to be iron-deficient, Landau says, your doctor will most likely start you on an oral supplement, which may be iron tablets or simply a multivitamin containing iron, depending on the amount you need.

If you’re found to have a severe iron deficiency, you may be given an intravenous (IV) iron infusion right away. This can help restore energy and resolve symptoms quickly.

You may also receive oral iron supplements, which will likely result in slow and steady progress rather than an instant improvement.

Landau notes that if a person doesn’t tolerate oral iron supplements well and experiences nausea, constipation, or diarrhea, that person may also be a candidate for IV iron, even if they’re not severely anemic. “Intravenous iron works fantastically,” he says, “if the patient can’t tolerate oral iron for any reason.”

While an iron-rich diet may help you maintain healthy iron levels, if you’re already anemic, Landau points out that dietary changes alone are unlikely to do you much good. “Diet, by itself, is an inefficient way to fix the iron issue,” he says.

Proper treatment of iron deficiency, according to Landau, can make a big difference for people with heart conditions. “If you fix the iron deficiency,” he says, “they usually feel better.”

EDITORIAL SOURCES
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Resources
  1. Iron-Deficiency Anemia. Cleveland Clinic. December 11, 2024.
  2. Anghel L et al. Iron Deficiency Treatment in Heart Failure—Challenges and Therapeutic Solutions. Journal of Clinical Medicine. April 24, 2025.
  3. Iron deficiency anemia. Mayo Clinic. September 20, 2025.
  4. Loncar G et al. Iron deficiency in heart failure. ESC Heart Failure. May 1, 2021.
  5. Savarese G et al. Iron deficiency and cardiovascular disease. European Heart Journal. January 1, 2023.
  6. Siddiqui SW et al. Anemia and Heart Failure: A Narrative Review. Cureus. July 23, 2022.
  7. Heart Failure. Mayo Clinic. January 21, 2025.
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Chung Yoon, MD

Medical Reviewer
Chung Yoon, MD, is a noninvasive cardiologist with a passion for diagnosis, prevention, intervention, and treatment of a wide range of heart and cardiovascular disorders. He enjoys...

Quinn Phillips

Author

A freelance health writer and editor based in Wisconsin, Quinn Phillips has a degree in government from Harvard University. He writes on a variety of topics, but is especially inte...