Ziihera (Intravenous)
Zanidatamab is used in adults to treat a certain type of bile duct or gallbladder cancer called biliary tract cancer.
Zanidatamab is used when the cancer was previously treated, has spread to other parts of the body (metastatic), or cannot be removed with surgery.
Your doctor will make sure you have the correct tumor type to be treated with zanidatamab.
Zanidatamab may also be used for purposes not listed in this medication guide.
uses
What is Ziihera (Intravenous) used for?
- Cholangiocarcinoma of biliary tract
warnings
What is the most important information I should know about Ziihera (Intravenous)?
Tell your doctor if you have or have ever had:
- heart problems.
You may need to have a negative pregnancy test before starting this treatment.
May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using zanidatamab and for at least 4 months after your last dose. Tell your doctor if you become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Side Effects
What are the side effects of Ziihera (Intravenous)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Some side effects may occur during or after the infusion. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Call your doctor at once if you have:
- new or worsening shortness of breath;
- feeling very tired;
- loss of consciousness;
- a new or a worsening irregular heartbeat pattern;
- dizziness, feeling light-headed;
- swelling or rapid weight gain; or
- severe diarrhea.
Your cancer treatments may be delayed, changed, or permanently discontinued if you have certain side effects.
Common side effects may include:
- infusion related reaction;
- diarrhea;
- stomach pain; or
- feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Ziihera (Intravenous) if I’m pregnant or breastfeeding?
You may need to have a negative pregnancy test before starting this treatment.
May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using zanidatamab and for at least 4 months after your last dose. Tell your doctor if you become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Interactions
What drugs and food should I avoid while taking Ziihera (Intravenous)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Ziihera (Intravenous)?
Use Ziihera (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Zanidatamab is given as a slow infusion into a vein. A healthcare provider will give you this injection.
Zanidatamab usually given once every 2 weeks. Your doctor will determine your treatment schedule.
You will be watched for a short time to make sure you do not have an allergic reaction.
Your heart function and blood will need to be tested before and during treatment. Your treatment may be changed based on the results.
You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
Call your doctor for instructions if you miss an appointment for your zanidatamab infusion.
Overdose Signs
What happens if I overdose on Ziihera (Intravenous)?
In a medical setting an overdose would be treated quickly.