Tnkase (Intravenous)
Tenecteplase is used in adults to treat a stroke caused by a clot (acute ischemic stroke) and to lower the risk of death from a certain type of heart attack.
Tenecteplase may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Tnkase (Intravenous)?
Do not use this medicine for a stroke if you have bleeding in your brain now, or for heart attack if you ever had bleeding in your brain or an ischemic stroke in the last 3 months.
You should not be treated with tenecteplase if you are allergic to it, or if you have:
- active bleeding inside your body;
- severe or uncontrolled high blood pressure;
- certain brain conditions that increase bleeding risk (such as a brain tumor, an aneurysm, or other abnormal blood vessel problems);
- a bleeding or blood clotting disorder (such as hemophilia); or
- if you had brain or spine injury or surgery within the past 2 months.
If possible before you receive tenecteplase, tell your doctor if you have ever had:
- bleeding in your brain, stomach, intestines, or urinary tract;
- heart problems, high blood pressure;
- history of stroke;
- an infection of the lining of your heart (subacute bacterial endocarditis);
- inflammation around the heart (acute pericarditis);
- if you are using a blood thinner or medicine used to prevent blood clots;
- bleeding in the eye caused by diabetes or other eye problems;
- severe inflammation or infection around a vein where an IV was placed;
- a recent serious injury, surgery, or procedure (for example, heart bypass, organ biopsy, or puncture of a large blood vessel); or
- severe liver or kidney disease.
If possible during an emergency, tell your medical caregivers if you are pregnant, recently delivered a baby, or are breastfeeding.
Side Effects
What are the side effects of Tnkase (Intravenous)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Tenecteplase increases your risk of bleeding even 1 or more days after receiving tenecteplase, which can be severe or life-threatening. Get emergency medical help if bleeding will not stop.
Call your doctor at once if you have:
- easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or injection site);
- bleeding inside your body--weakness, pink or brown urine, abnormal vaginal bleeding, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot in the lung--chest pain, sudden cough or shortness of breath, dizziness, coughing up blood;
- signs of a blood clot deep in the body--pain, swelling, or warmth in one leg; or
- very slow or fast heartbeats, shortness of breath, or feeling light-headed.
Common side effects may include:
- bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Tnkase (Intravenous) if I’m pregnant or breastfeeding?
If possible during an emergency, tell your medical caregivers if you are pregnant, recently delivered a baby, or are breastfeeding.
Interactions
What drugs and food should I avoid while taking Tnkase (Intravenous)?
Ask your doctor before taking aspirin, ibuprofen, naproxen, or another nonsteroidal anti-inflammatory drug (NSAID) soon after you receive tenecteplase. These medicines can increase your risk of bleeding.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Dosage Guidelines & Tips
How to take Tnkase (Intravenous)?
Use Tnkase (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Tenecteplase is injected into a vein. A healthcare provider will give you this injection.
Tenecteplase is usually given as soon as possible after the first signs of a heart attack or stroke occur.
You will be watched for a certain amount of time to make sure you do not have an allergic reaction. You may be given other medications to help treat serious side effects or allergic reactions.
Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using tenecteplase.
In an emergency medical setting, you are not likely to miss a dose.
Overdose Signs
What happens if I overdose on Tnkase (Intravenous)?
In a medical setting an overdose would be treated quickly.