Tislelizumab (Intravenous)
Tislelizumab is used in adults to treat cancer of esophagus that has spread to other parts of the body (metastatic) or cannot be removed with surgery.
Your doctor will make sure you have correct tumor type to be treated with tislelizumab.
Tislelizumab may also be used for purposes not listed in this medication guide.
uses
What is Tislelizumab (Intravenous) used for?
- Esophageal Carcinoma
- Gastric Cancer
warnings
What is the most important information I should know about Tislelizumab (Intravenous)?
Tell your doctor if you have ever had:
- an autoimmune disorder such as Crohn's disease, ulcerative colitis, lupus;
- an organ transplant, or a stem cell transplant from a donor;
- radiation treatment to the chest area; or
- a nerve-muscle disorder, such as myasthenia gravis, or Guillain-Barré syndrome.
You may need to have a negative pregnancy test before starting this treatment.
May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using tislelizumab and for at least 4 months after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 4 months after your last dose.
Side Effects
What are the side effects of Tislelizumab (Intravenous)?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Serious and sometimes fatal reactions may occur during treatment with tislelizumab or months after your last dose. Call your doctor right away if you have symptoms such as:
- symptoms of brain swelling--confusion, headache, memory problems, hallucinations, neck stiffness, drowsiness, seizure (convulsions).
- lung problems--new or worsening cough, chest pain, feeling short of breath;
- liver problems--right-sided upper stomach pain, tiredness, bruising or bleeding, dark urine, yellowing of your skin or eyes;
- signs of a hormonal disorder--frequent or unusual headaches, lack of energy, dizziness, fainting, mood or behavior changes, increased thirst or urination, feeling cold, weight gain, or weight loss;
- kidney problems--little or no urination, swelling in your feet or ankles, blood in your urine;
- (if you have had a stem cell transplant) feeling sick or uneasy, with pain or swelling;
- new or worsening skin rash, itching, or blistering;
- fever, swollen glands, body aches;
- chest pain, irregular heartbeats;
- severe muscle weakness, ongoing pain in your muscles or joints;
- numbness or tingling in your hands or feet; or
- vision problems, eye pain or redness.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- pain in your muscles, joints, or bones;
- weight loss;
- fever, cough, shortness of breath;
- nausea, vomiting, stomach pain, loss of appetite;
- diarrhea, constipation;
- hormonal problems;
- rash or itching; or
- headache, dizziness, tiredness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Tislelizumab (Intravenous) if I’m pregnant or breastfeeding?
You may need to have a negative pregnancy test before starting this treatment.
May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using tislelizumab and for at least 4 months after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 4 months after your last dose.
Interactions
What drugs and food should I avoid while taking Tislelizumab (Intravenous)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Tislelizumab (Intravenous)?
Use Tislelizumab (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Tislelizumab is injected into a vein by a healthcare provider.
This medicine must be given slowly, and the infusion can take 30 to 60 minutes to complete.
Tislelizumab is usually given once every 3 weeks. Your doctor will determine how long to treat you with this medicine.
You may be given other medications to treat or prevent certain side effects.
You may need frequent medical tests and your cancer treatments may be delayed based on the results.
Call your doctor for instructions if you miss an appointment for your tislelizumab injection.