Spevigo (Intravenous)
Spesolimab is used to treat a certain type of psoriasis called generalized pustular psoriasis (GPP) in adults and children of age 12 years or older and weighing at least 88.2 pounds (40 kg).
Spesolimab may also be used for purposes not listed in this medication guide.
uses
What is Spevigo (Intravenous) used for?
- Pustular Psoriasis
warnings
What is the most important information I should know about Spevigo (Intravenous)?
You should not use spesolimab if you are allergic to it.
Tell your doctor if you have:
- tuberculosis or have been exposed to tuberculosis;
- an infection that keeps returning or does not go away; or
- recently received or are scheduled to receive a vaccine.
Tell your doctor if you are pregnant or breastfeeding.
Side Effects
What are the side effects of Spevigo (Intravenous)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Call your doctor at once if you have:
- signs of an infection--fever, chills, sweats, cough, shortness of breath, blood in your mucus, any burning when you urinate, or if you urinate more than usual.
Common side effects may include:
- tiredness or weakness;
- nausea, vomiting;
- headache;
- itching or itchy bumps;
- bruising or blood under the skin where the injection was given; or
- pain or burning when you urinate.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Spevigo (Intravenous) if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or breastfeeding.
Interactions
What drugs and food should I avoid while taking Spevigo (Intravenous)?
Avoid receiving a "live" vaccine while you are being treated with spesolimab and for at least 16 weeks after the treatment. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).
Dosage Guidelines & Tips
How to take Spevigo (Intravenous)?
Use Spevigo (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets.
Spesolimab is injected into a vein by a healthcare provider over 90 minutes.
Spesolimab intravenous is given usually once. If your symptoms continue, your healthcare provider may give you an additional treatment with this medicine after 1 week.
Spesolimab can also be injected under the skin in the upper thigh or stomach area once every 4 weeks.
Your healthcare provider will show you where to inject spesolimab. Do not inject into the same place two times in a row. Avoid injecting into skin that is hard, red, bruised, swollen, or tender.
Make sure you are current on all vaccines before you start using spesolimab.
Before you use spesolimab, your doctor will test you for tuberculosis or other infections.
Use the medicine as soon as you remember, and then go back to your regular schedule. Do not use two doses at one time.