Sinemet CR (Oral)
Carbidopa and levodopa may be used alone or in combination with other medication to treat symptoms of Parkinson's disease, such as stiffness or tremors in adults.
Carbidopa and levodopa is also used in adults to treat Parkinson's disease caused by infection, carbon monoxide poisoning or manganese intoxication.
Carbidopa and levodopa may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Sinemet CR (Oral)?
You should not use carbidopa and levodopa if you are allergic to it or any of its ingredients, or if you have narrow-angle glaucoma.
It is not known if carbidopa and levodopa will harm an unborn baby. The benefit of this treatment may outweigh any risks to the mother and baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Do not use carbidopa and levodopa if you have used a MAO inhibitor in the past 14 days.Wait at least 14 days after stopping an MAO inhibitor before you take carbidopa and levodopa. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.
If you already take levodopa, you must stop taking it at least 12 hours before you start taking carbidopa and levodopa.
Tell your doctor if you have or have ever had:
The may contain phenylalanine and could be harmful if you have phenylketonuria (PKU). Ask your doctor about your risk. orally disintegrating tablet
Some people have thoughts about suicide while taking carbidopa and levodopa. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.
People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for.
- an endocrine disease, heart disease, high blood pressure, or heart attack;
- asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;
- skin cancer (melanoma), a stomach or intestinal ulcer;
- glaucoma, depression, mental illness, or psychosis;
- if you received general anesthesia; or
- liver or kidney disease.
Side Effects
What are the side effects of Sinemet CR (Oral)?
Get emergency medical help if you have : hives, difficult breathing, swelling of your face, lips, tongue, or throat. signs of an allergic reaction
Some people taking carbidopa and levodopa have fallen asleep during normal daytime activities such as working or driving after starting this medicine and up to a year after. Tell your doctor if you have any problems with daytime sleepiness.
Call your doctor at once if you have:
Tell your doctor right away if you have new or sudden changes in mood or behavior, including depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, aggressive, more active or talkative, or have thoughts about suicide or hurting yourself.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.
Your dose may be reduced or permanently discontinued if you have certain side effects.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
- signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- uncontrolled muscle movements, blurred vision, eye pain or redness, seeing halos around lights; or
- severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
- uncontrolled muscle movements;
- dry mouth, anxiety, headache, dizziness;
- drops in blood pressure or feeling light-headed when standing up;
- sleep problems (insomnia), strange dreams, muscle contractions; or
- nausea, vomiting, constipation.
Pregnancy & Breastfeeding
Can I take Sinemet CR (Oral) if I’m pregnant or breastfeeding?
It is not known if carbidopa and levodopa will harm an unborn baby. The benefit of this treatment may outweigh any risks to the mother and baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Interactions
What drugs and food should I avoid while taking Sinemet CR (Oral)?
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Also avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Drinking alcohol with this medicine can cause side effects.
Avoid taking iron supplements, high-fat, or high-calorie meals before or after taking carbidopa and levodopa. These can make it harder for your body to absorb carbidopa and levodopa.
Dosage Guidelines & Tips
How to take Sinemet CR (Oral)?
Use Sinemet CR (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Stop taking any other medications that contain carbidopa and levodopa when you start taking the form. extended-release
Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using exactly as directed on the label, or as prescribed by your doctor.
Take this medicine at evenly spaced intervals. Follow your doctor's instructions about whether to take your medication with food or on an empty stomach.
If you cannot swallow an extended-release capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing.
Remove an from the package with dry hands only when you are ready to use the medicine. Allow the to dissolve in your mouth without chewing. orally disintegrating tabletorally disintegrating tablet
Carbidopa and levodopa will most likely darken the color of your saliva, urine, or sweat to an orange or red color. This is a normal effect and is not harmful. This may also cause stains to your underwear that may be permanent.
You may need frequent medical tests and your doctor will need to check your progress on a regular basis.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using carbidopa and levodopa.
Do not stop using carbidopa and levodopa suddenly, or you could have unpleasant withdrawal symptoms (such as agitation, confusion, tingling). Ask your doctor before stopping the medicine.
You may need to follow a special diet. Learn about the foods you should eat or avoid.
Swallow the whole and do not crush, chew, break, or open it. The is sometimes broken in half to give the correct dose. Always swallow a without chewing or crushing. capsuletabletwhole or half tablet
It may take up to several weeks before your symptoms improve. Tell your doctor if your symptoms do not improve or if the effects of this medicine wear off quickly between doses.
Store tightly closed at room temperature, away from moisture, heat, and light.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. take two doses at one time. Do not
Get your prescription refilled before you run out of medicine completely.
Overdose Signs
What happens if I overdose on Sinemet CR (Oral)?
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