Question 1

What is Selpercatinib (Oral) used for?

Accepted Answer

Non-Small Cell Lung Cancer
Solid Tumors
Thyroid Cancer

Question 2

What is the most important information I should know about Selpercatinib (Oral)?

Accepted Answer

Tell your doctor if you have or ever had:

bleeding problems;
lung or breathing problems other than lung cancer;
high blood pressure;
recent or planned surgery;
thyroid problems other than thyroid cancer;
heart problems including long QT syndrome (in you or a family member); or
liver disease.

Selpercatinib can harm an unborn baby if the mother or the father is using this medicine.

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 1 week after your last dose.
If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 week after your last dose.
Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby. Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Question 3

Can I take Selpercatinib (Oral) if I’m pregnant or breastfeeding?

Accepted Answer

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Question 4

How to take Selpercatinib (Oral)?

Accepted Answer

Use Selpercatinib (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Selpercatinib is usually taken twice daily with or without food. Take selpercatinib with food if you also use a stomach acid medicine such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, rabeprazole, and others. Swallow whole and do not crush, chew, break, or open it. Drink plenty of liquids while you are taking selpercatinib. If you vomit shortly after taking selpercatinib, do not take another dose. Take your next dose as scheduled. Doses are based on body surface area (height and weight) in children. Your child's dose may change if they gain or lose weight or if they are still growing. Doses are based on weight in adults. Your dose may change if you gain or lose weight. You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed. Your blood pressure will need to be checked often. You will need frequent medical tests, and your dose or medication schedule may be changed based on the results. If you need surgery, tell the surgeon ahead of time that you are using selpercatinib. You may need to stop using the medicine for a short time. Store at room temperature away from moisture and heat.

Question 5

What happens if I overdose on Selpercatinib (Oral)?

Accepted Answer

If you think you or someone else may have overdosed Selpercatinib (Oral) call your doctor or the Poison Control center '800-222-1222','(800) 222-1222','Poison Control' If someone collapses or isn't breathing after taking Diclofenac (Voltaren), call 911

Question 6

What drugs and food should I avoid while taking Selpercatinib (Oral)?

Accepted Answer

Ask your doctor before taking any medicine to reduce stomach acid. Take only the type your doctor recommends. Avoid taking an herbal supplement containing St. John's Wort.

Question 7

What are the side effects of Selpercatinib (Oral)?

Accepted Answer

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat. You may feel faint while taking selpercatinib. Call your doctor right away if you have fast or pounding heartbeats, shortness of breath, and sudden dizziness. Call your doctor at once if you have:

unusual bleeding or signs of bleeding inside your body--bruising, nosebleeds, bleeding gums, abnormal vaginal bleeding, any bleeding that will not stop, weakness, dizziness, pink or brown urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
any wound that will not heal;
pain in your knees or hips, walking with a limp;
severe headache, blurred vision, pounding in your neck or ears;
signs of tumor cell breakdown--tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth;
underactive thyroid--tiredness, depressed mood, dry skin, thinning hair, decreased sweating, weight gain, puffiness in your face, feeling more sensitive to cold temperatures;
sudden chest pain, wheezing, new or worsening cough, feeling short of breath or trouble breathing; or
liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include:

abnormal blood tests;
high blood pressure;
fever, tiredness, headache;
bleeding;
dry mouth;
bone, muscle, or stomach pain;
nausea, vomiting, constipation, or diarrhea;
swelling;
coronavirus infection; or
rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.