Metformin And Sitagliptin - Side Effects, Interactions, Uses, Dosage, Warnings

Metformin And Sitagliptin (Oral)

Metformin And Sitagliptin (Oral)

Metformin and sitagliptin is a combination medicine used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus (not for type 1 diabetes).

Metformin and sitagliptin may also be used for purposes not listed in this medication guide.

uses

What is Metformin And Sitagliptin (Oral) used for?

warnings

What is the most important information I should know about Metformin And Sitagliptin (Oral)?

You should not use metformin and sitagliptin if you are allergic to it, or if you have severe kidney disease or metabolic acidosis (including diabetic ketoacidosis).

Tell your doctor if you have or have ever had:

  • heart problems such as heart attack, heart failure, or stroke;
  • pancreatitis;
  • low levels of vitamin B12 or calcium in your blood;
  • high triglycerides (a type of fat in the blood);
  • gallstones;
  • alcoholism; or
  • liver or kidney disease.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking metformin and sitagliptin. Make sure that your healthcare provider knows ahead of time that you are using this medication.

It is not known if metformin and sitagliptin will harm an unborn baby. Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

This medicine may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk

Ask a doctor if it is safe to breastfeed while using this medicine.

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Side Effects

What are the side effects of Metformin And Sitagliptin (Oral)?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop taking this medicine and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

Some people using metformin and sitagliptin develop lactic acidosis, which can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heartbeats, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have any of these serious side effects:

  • severe or ongoing pain in your joints;
  • a severe skin reaction-- itching, blisters, breakdown of the outer layer of skin;
  • kidney problems or symptoms of heart failure--swelling, urinating less, rapid weight gain, feeling tired or short of breath; or
  • severely low blood sugar--extreme weakness, confusion, tremors, sweating, fast heartbeats, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

Common side effects may include:

  • low blood sugar (if you also use insulin or another oral diabetes medication);
  • upset stomach, indigestion, gas, diarrhea, nausea, vomiting;
  • headache, weakness; or
  • cold symptoms such as runny or stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Metformin And Sitagliptin (Oral) if I’m pregnant or breastfeeding?

It is not known if metformin and sitagliptin will harm an unborn baby. Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

This medicine may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk

Ask a doctor if it is safe to breastfeed while using this medicine.

Interactions

What drugs and food should I avoid while taking Metformin And Sitagliptin (Oral)?

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

Dosage Guidelines & Tips

How to take Metformin And Sitagliptin (Oral)?

Use Metformin And Sitagliptin (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Metformin and sitagliptin is usually taken either once or twice a day based on the form of this medicine. Follow your doctor's instructions.

Take metformin and sitagliptin with meals. Take the extended-release tablet once daily with your meal.

Swallow the tablet whole and do not crush, chew, or break it.

You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting, diarrhea, fever, or if you drink liquids less than usual.

Call your doctor if you see the extended-release tablet in your stool several times.

Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.

Low blood sugar (hypoglycemia) can make you feel very hungry, dizzy, irritable, or shaky. To quickly treat hypoglycemia, eat or drink hard candy, crackers, raisins, fruit juice, or non-diet soda. Your doctor may prescribe glucagon injection in case of severe hypoglycemia.

Tell your doctor if you have frequent symptoms of high blood sugar (hyperglycemia) such as increased thirst or urination. Ask your doctor before changing your medication dosage.

Your blood sugar will need to be checked on a regular basis, and you may need other medical tests including checking your kidney function.

You may be given other medications to help with your condition. Keep taking these medicines for as long as your doctor has prescribed.

Your treatment may also include diet, exercise, weight control, and special medical care.

Store at room temperature away from moisture and heat. Certain brands must be stored in the original container and used within 1 to 3 months.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Overdose Signs

What happens if I overdose on Metformin And Sitagliptin (Oral)?

If you think you or someone else may have overdosed on: Metformin And Sitagliptin (Oral),  call your doctor or the Poison Control center
(800) 222-1222
If someone collapses or isn't breathing after taking Metformin And Sitagliptin (Oral), call 911
911

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Medical Disclaimer

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health.