Linaclotide - Side Effects, Interactions, Uses, Dosage, Warnings

Linaclotide (Oral)

Linaclotide (Oral)

Brand Names:Linzess

Linaclotide is used to treat long-lasting stomach and bowel problems, including:

  • irritable bowel syndrome with constipation (can cause belly pain and constipation) in adults and children ages 7 years and older;
  • chronic idiopathic constipation (long-lasting constipation with no known cause) in adults; and
  • functional constipation (long-lasting constipation not caused by a disease) in children ages 6 years and older.

Linaclotide may also be used for purposes not listed in this medication guide.

uses

What is Linaclotide (Oral) used for?

warnings

What is the most important information I should know about Linaclotide (Oral)?

You should not use linaclotide if you are allergic to it, or if you have:

  • a blockage in your intestines (bowel obstruction).

Do not give linaclotide to children younger than 2 years old, even by accident. It can cause severe diarrhea and severe dehydration.

Tell your doctor if you are pregnant or plan to become pregnant, or if you are breastfeeding or plan to breastfeed.

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Side Effects

What are the side effects of Linaclotide (Oral)?

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Stop using linaclotide and call your doctor at once if you have:

  • severe stomach pain, especially if you also have blood in your stool or black stools that look like tar;
  • severe or ongoing diarrhea; or
  • diarrhea with dizziness or a light-headed feeling (like you might pass out).

Common side effects may include:

  • bloating, gas;
  • diarrhea;
  • stomach pain; or
  • swelling, or a feeling of fullness or pressure in your stomach area.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Linaclotide (Oral) if I’m pregnant or breastfeeding?

Tell your doctor if you are pregnant or plan to become pregnant, or if you are breastfeeding or plan to breastfeed.

Interactions

What drugs and food should I avoid while taking Linaclotide (Oral)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dosage Guidelines & Tips

How to take Linaclotide (Oral)?

Use Linaclotide (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Linaclotide is usually taken once per day an empty stomach, at least 30 minutes before a meal, at about the same time each day.

Swallow the capsule whole. Do not crush or chew the capsule or what is inside it.

If you cannot swallow the capsule whole, you may open it and sprinkle the beads on applesauce or mix them with bottled water. Swallow right away. Do not chew the beads. Do not save the mixture for later. Do not mix the beads with other foods or liquids.

If you take linaclotide with applesauce or mixed with water, wait at least 30 minutes before you eat a meal.

Linaclotide may also be given through a feeding tube. Ask your doctor or pharmacist if you do not understand these instructions.

Call your doctor if your symptoms do not improve, or if they get worse.

Linaclotide may cause severe diarrhea. This can lead to dehydration (losing too much body water). Stop taking linaclotide and call your doctor right away if you get severe diarrhea.

Store at room temperature away from moisture and heat. Keep the capsules in their original container, along with the packet or canister of moisture-absorbing preservative.

Keep this medicine out of the reach of children. If a child swallows linaclotide by accident, it may cause severe diarrhea and severe dehydration. Get emergency medical help right away.

Skip the missed dose and use your next dose at the regular time. Do not take two doses at one time.

Overdose Signs

What happens if I overdose on Linaclotide (Oral)?

If you think you or someone else may have overdosed on: Linaclotide (Oral),  call your doctor or the Poison Control center
(800) 222-1222
If someone collapses or isn't breathing after taking Linaclotide (Oral), call 911
911

Images

FL 145

Color: white

Shape: capsule

Imprint: FL 145

FL 290

Color: white

Shape: capsule

Imprint: FL 290

Medical Disclaimer

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health.