Lazcluze (Oral)
Lazertinib is used in combination with amivantamab to treat adults with certain type of non-small cell lung cancer that has spread to other parts of the body (metastatic) or cannot be removed by surgery.
Your doctor will make sure you have the correct tumor type to be treated with lazertinib.
Lazertinib may also be used for purposes not listed in this medication guide.
uses
What is Lazcluze (Oral) used for?
- Non-Small Cell Lung Cancer
warnings
What is the most important information I should know about Lazcluze (Oral)?
Tell your doctor if you have or have ever had:
- lung or breathing problems other than lung cancer.
Lazertinib can harm an unborn baby if the mother or the father is using this medicine.
- If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 3 week after your last dose.
- If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 week after your last dose.
- Tell your doctor right away if a pregnancy occurs.
Do not breastfeed while using this medicine, and for at least 3 weeks after your last dose.
Lazertinib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.
Side Effects
What are the side effects of Lazcluze (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- severe skin reactions--small, raised, acne-like bumps, skin rash, itching, or dryness;
- eye problems--eye pain or redness, itching, dry or watery eyes, increased sensitivity to light, or changes in your vision such as blurred vision;
- signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot in the lung--chest pain, sudden cough or shortness of breath, dizziness, coughing up blood; or
- signs of a blood clot deep in the body--pain, swelling, or warmth in one leg.
Your cancer treatments may be delayed, reduced, or permanently discontinued if you have certain side effects.
Common side effects may include:
- tingly feeling or unusual skin sensations;
- infected skin around the nail;
- diarrhea or constipation;
- bleeding, mouth sores;
- nausea, loss of appetite;
- muscle or joint pain;
- itchy skin rash;
- tiredness;
- swelling in your face or any other part of your body; or
- abnormal blood tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Lazcluze (Oral) if I’m pregnant or breastfeeding?
Do not breastfeed while using this medicine, and for at least 3 weeks after your last dose.
Interactions
What drugs and food should I avoid while taking Lazcluze (Oral)?
Lazertinib could make you sunburn more easily. Avoid sunlight or tanning beds during treatment and for at least 2 months after your last dose. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors and use alcohol-free moisturizing cream.
If you have vision problems, avoid wearing contact lenses until your symptoms can be checked by an eye doctor (ophthalmologist).
Dosage Guidelines & Tips
How to take Lazcluze (Oral)?
Use Lazcluze (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Your doctor will perform tests to make sure lazertinib is the right treatment for you.
Lazertinib is usually taken once per day with or without food on the same day of before receiving your infusion with amivantamab.
Swallow the tablet whole and do not crush, chew, or break it.
You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed.
If you vomit shortly after taking lazertinib, do not take another dose. Take your next dose as scheduled.
You will need frequent medical tests, and your dose or medication schedule may be changed based on the results.
Do not change your dose or stop using this medicine without your doctor's advice. Do not start or stop any medicine without asking your doctor.
Store in the original package at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if your next dose is due within 12 hours. Do not take two doses at one time.
Overdose Signs
What happens if I overdose on Lazcluze (Oral)?
Images
LZ, 80
Color: yellow
Shape: oval
Form: film coated
Imprint: LZ, 80
LZ, 240
Color: purple
Shape: oval
Form: film coated
Imprint: LZ, 240