Donidalorsen (Subcutaneous)
Donidalorsen is used in adults and children at least 12 years old to prevent attacks of hereditary angioedema (HAE).
Donidalorsen may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Donidalorsen (Subcutaneous)?
You should not use donidalorsen if you are allergic to it or any of its ingredients.
Tell your doctor if you have or have ever had:
- low levels of platelets in your blood; or
- liver disease.
It is not known if donidalorsen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Side Effects
What are the side effects of Donidalorsen (Subcutaneous)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- chest pain;
- fainting, dizziness, feeling light-headed; or
- easy bruising, unusual bleeding, purple or red spots under your skin.
Common side effects may include:
- pain, bruising, swelling, or irritation where the medicine was injected;
- stomach discomfort;
- pain and burning when you urinate; or
- cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Donidalorsen (Subcutaneous) if I’m pregnant or breastfeeding?
It is not known if donidalorsen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Interactions
What drugs and food should I avoid while taking Donidalorsen (Subcutaneous)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Donidalorsen (Subcutaneous)?
Use Donidalorsen (Subcutaneous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Donidalorsen is injected under the skin, usually once every 4 or 8 weeks. A healthcare provider may give you this injection or may teach you or your caregiver how to properly use this medicine.
Read and carefully follow the Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand how to use an injection.
Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it.
Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before using. Do not warm the medicine with hot water, sunlight, or a microwave.
Do not inject within 2 inches of your navel (belly button), or areas where the skin is hard, tender, bruised, red, or has scars. Do not inject into the same place two times in a row.
You may need blood tests to check your platelets and liver function.
Throw away the autoinjector after one use, even if there is still medicine left inside. Do not reuse a needle or autoinjector. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.
Store this medicine in the original carton in the refrigerator. Protect from light and do not freeze.
You may store this medicine at room temperature for up to 6 weeks. Throw the medicine away if not used within 6 weeks. Protect from heat.
Use the medicine as soon as you remember, and then go back to your regular schedule. Do not use two doses at one time.