Denileukin Diftitox (Intravenous)
Denileukin Diftitox (Intravenous)
Denileukin diftitox is used in adults to treat cutaneous (of the skin) T-cell lymphoma after at least one other treatment did not work or stopped working.
Denileukin diftitox may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Denileukin Diftitox (Intravenous)?
Tell your doctor if you have or have ever had:
- vision problems; or
- liver disease.
May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using Denileukin diftitox and for at least 7 days after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 7 days after your last dose.
Side Effects
What are the side effects of Denileukin Diftitox (Intravenous)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Capillary leak syndrome is a rare but serious side effect. Call your doctor right away if you have signs of this condition: low blood pressure, stuffy or runny nose followed by tiredness, thirst, decreased urination, trouble breathing, and sudden swelling or weight gain.
Call your doctor at once if you have:
- blurred vision, changes in clarity, sharpness, or color vision; or
- liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Your cancer treatments may be delayed, reduced, or permanently discontinued if you have certain side effects.
Common side effects may include:
- nausea, constipation;
- rash, chills, fever;
- swelling in any part of your body;
- feeling very tired;
- bone, muscle, or joint pain; or
- abnormal blood tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Denileukin Diftitox (Intravenous) if I’m pregnant or breastfeeding?
May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using Denileukin diftitox and for at least 7 days after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 7 days after your last dose.
Interactions
What drugs and food should I avoid while taking Denileukin Diftitox (Intravenous)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Denileukin Diftitox (Intravenous)?
Use Denileukin Diftitox (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Your doctor will perform tests to make sure denileukin diftitox is the right treatment for you.
Denileukin diftitox is injected into a vein by a healthcare provider.
Denileukin diftitox is given in a 21-day treatment cycle. You will receive an injection only on certain days of this cycle.
After receiving an injection, you will be watched closely to make sure you do not have an allergic reaction or serious side effects.
Your healthcare provider may give other medications to help prevent an allergic reaction or serious side effects.
You may need frequent medical tests including vision exams.
Doses are based on weight. Your dose may change if you gain or lose weight.
Call your doctor for instructions if you miss an appointment for your denileukin diftitox injection.
Overdose Signs
What happens if I overdose on Denileukin Diftitox (Intravenous)?
In a medical setting an overdose would be treated quickly.