Daurismo (Oral)
Glasdegib is used in adults in combination with cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot receive chemotherapy due to other medical conditions.
Glasdegib may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Daurismo (Oral)?
Tell your doctor if you have ever had:
- heart problems;
- long QT syndrome (in you or a family member);
- an electrolyte imbalance (such as low blood levels of potassium or magnesium);
- muscle pain or muscle spasms;
- kidney disease; or
- liver disease.
You will need to take a pregnancy test within 7 days of starting treatment with glasdegib.
May harm an unborn baby. You will need a pregnancy test to make sure you are not pregnant. Use effective birth control while using glasdegib and for at least 30 days after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 30 days after your last dose.
Men using glasdegib should use condoms during treatment, even after a vasectomy and for at least 30 days after treatment ends.
It may be harder for you to get a woman pregnant while you are using this medicine.
Side Effects
What are the side effects of Daurismo (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- irregular or fast heartbeats, shortness of breath, and sudden dizziness (like you might pass out);
- easy bruising, unusual bleeding, purple or red spots under your skin;
- any new or worsening muscle pain or muscle spasms; or
- low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- bleeding;
- fever, low blood cell counts;
- changes in your sense of taste;
- pain or sores in mouth or throat;
- loss of appetite, constipation, nausea;
- rash;
- muscle pain;
- swelling in your arms or legs;
- feeling tired; or
- trouble breathing.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Daurismo (Oral) if I’m pregnant or breastfeeding?
You will need to take a pregnancy test within 7 days of starting treatment with glasdegib.
May harm an unborn baby. You will need a pregnancy test to make sure you are not pregnant. Use effective birth control while using glasdegib and for at least 30 days after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 30 days after your last dose.
Interactions
What drugs and food should I avoid while taking Daurismo (Oral)?
Do not donate blood while taking glasdegib, and for at least 30 days following your last dose.
Do not donate semen while you are taking glasdegib, and for at least 30 days after your last dose.
Dosage Guidelines & Tips
How to take Daurismo (Oral)?
Use Daurismo (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Glasdegib is given in a 28-day treatment cycle, usually for a total of 6 cycles. Glasdegib is taken by mouth. Your doctor will determine how long to treat you with this medicine.
Take the medicine once a day at the same time each day, with or without food.
Swallow the tablet whole and do not crush, chew, or break it.
If you vomit shortly after taking glasdegib, do not take another dose. Take your next dose as scheduled.
Your heart function may need to be checked using an electrocardiogram or ECG (sometimes called an EKG).
You will need frequent medical tests and your cancer treatments may be delayed based on the results.
Store at room temperature away from moisture and heat.
Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses within 12 hours.
Overdose Signs
What happens if I overdose on Daurismo (Oral)?
Overdose symptoms may include tiredness, nausea, vomiting, dizziness, feeling like you might pass out, thirst, and little or no urination.
Images
Pfizer, GLS 100
Color: orange
Shape: round
Form: film coated
Imprint: Pfizer, GLS 100
Pfizer, GLS 25
Color: yellow
Shape: round
Form: film coated
Imprint: Pfizer, GLS 25