Cobenfy (Oral)
Trospium and xanomeline is a combination medicine used in adults to treat schizophrenia.
Trospium and xanomeline may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Cobenfy (Oral)?
You should not take trospium and xanomeline if you are allergic to it, or if you have:
- urinary retention (trouble urinating);
- slow digestion (slowed movement of food from the stomach to the small intestine);
- untreated narrow angle glaucoma; or
- moderate to severe liver disease.
Tell your doctor if you have or have ever had:
- problems with urination such as bladder obstruction or enlarge prostate;
- gallstones;
- problems with your bile ducts or pancreas;
- an intestinal disorder such as ulcerative colitis;
- a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion;
- constipation;
- myasthenia gravis;
- narrow-angle glaucoma; or
- liver or kidney disease.
It is not known if trospium and xanomeline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trospium and xanomeline on the baby.
Ask a doctor if it is safe to breastfeed while using this medicine.
Side Effects
What are the side effects of Cobenfy (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- racing or pounding heartbeats;
- heartburn, bloating;
- upset stomach or burning, upper stomach pain that may spread to your back;
- nausea, vomiting;
- stomach pain, constipation;
- confusion, sleep problems (insomnia), hallucinations (seeing or hearing things that are not real);
- fever, pain in your side or lower back, painful or difficult urination, increased urination, blood or pus in your urine;
- blurred vision, eye pain or redness, severe headache, seeing halos around lights; or
- liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Your doctor may need to adjust the dose or permanently discontinued your treatment with trospium and xanomeline if you have certain side effects.
Common side effects may include:
- a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion;
- upset stomach, constipation, or diarrhea;
- stomach pain or burning;
- nausea, vomiting;
- high blood pressure; or
- dizziness, fast heart rate.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Cobenfy (Oral) if I’m pregnant or breastfeeding?
It is not known if trospium and xanomeline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trospium and xanomeline on the baby.
Ask a doctor if it is safe to breastfeed while using this medicine.
Interactions
What drugs and food should I avoid while taking Cobenfy (Oral)?
Avoid driving or hazardous activity until you know how this medicine will affect you. Confusion, dizziness or drowsiness can cause falls, accidents, or severe injuries.
Dosage Guidelines & Tips
How to take Cobenfy (Oral)?
Use Cobenfy (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Trospium and xanomeline is usually taken twice per day.
Take on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not change your dose or stop using a medicine without your doctor's advice.
You may need liver function tests before starting treatment and while using this medicine.
You may need medical tests before starting treatment and while using this medicine to check your heart function.
Swallow the capsule whole and do not crush, chew, break, or open it.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Overdose Signs
What happens if I overdose on Cobenfy (Oral)?
Images
Karuna 50/20 mg
Color: buff
Shape: capsule
Imprint: Karuna 50/20 mg
Karuna 100 20 mg
Color: brown
Shape: capsule
Imprint: Karuna 100 20 mg
Karuna 125/30 mg
Color: orange
Shape: capsule
Imprint: Karuna 125/30 mg