Adagrasib (Oral)
Adagrasib is used in adults to treat non-small cell lung cancer.
Adagrasib is also used in adults to treat colorectal cancer.
Adagrasib is used when the cancer has spread to other parts of the body (metastatic), or cannot be removed by surgery.
Adagrasib can be used alone or in combination with other cancer drugs.
Adagrasib is sometimes given after other cancer treatments did not work or have stopped working.
Your doctor may perform a biopsy to test your cancer for a specific genetic marker (an abnormal "KRAS G12C" gene).
Adagrasib may also be used for purposes not listed in this medication guide.
uses
What is Adagrasib (Oral) used for?
- Non-Small Cell Lung Cancer
warnings
What is the most important information I should know about Adagrasib (Oral)?
Tell your doctor if you have ever had:
- heart problems, including heart failure and congenital long QT syndrome; or
- liver problems.
It is not known if adagrasib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Adagrasib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Side Effects
What are the side effects of Adagrasib (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- nausea, diarrhea, or vomiting;
- lung disease, or breathing problems;
- cough or fever;
- bowel obstruction, colitis, severe constipation;
- fast or pounding heartbeats, fluttering in your chest, and sudden dizziness (like you might pass out);
- stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
- liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- anemia (low red blood cells);
- nausea, diarrhea, vomiting;
- skin rash, dry skin;
- dizziness, tiredness;
- muscle and bone pain;
- cough, trouble breathing;
- severe numbness or tingling in your arms or legs;
- stomach pain, constipation, loss of appetite; or
- swelling, urinating less, feeling tired or short of breath.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Adagrasib (Oral) if I’m pregnant or breastfeeding?
It is not known if adagrasib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Interactions
What drugs and food should I avoid while taking Adagrasib (Oral)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Adagrasib (Oral)?
Use Adagrasib (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take adagrasib twice a day with or without food, at the same time each day.
Do not change your dose or stop using this medication without your doctor's advice.
Swallow the tablet whole and do not crush, chew, or break it.
If you vomit shortly after taking adagrasib, do not take another dose. Take your next dose as scheduled.
You may be given medication to prevent nausea or vomiting while you are receiving adagrasib.
Your treatment may be changed or permanently discontinued if you have certain side effects.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using adagrasib.
You will need medical tests before and during treatment with adagrasib.
You may need medical tests to check your heart function and electrolytes.
Store at room temperature away from moisture and heat.
Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.
Overdose Signs
What happens if I overdose on Adagrasib (Oral)?
Images
M, 200
Color: white
Shape: oval
Form: film coated
Imprint: M, 200