LARS: The Colorectal Cancer Surgery Side Effect No One Talks About

What Is LARS?
Signs and Symptoms to Watch for
- Increased frequency or urgency of bowel movements
- A feeling of needing to defecate even when your bowel is empty
- Involuntary leaking of gas and stool
- Change in stool consistency
- Difficult or painful bowel movements
- Abdominal pain
It’s natural to feel embarrassed about sharing these types of symptoms with your doctor. “I find people don't necessarily bring it up on their own because there's a certain stigma associated with bowel movements,” says Jeongyoon Moon, MD, assistant professor of colon and rectal surgery at the University of Texas MD Anderson Cancer Center in Houston.
Treatments and Symptom Management
Lifestyle Changes
Keeping a food and symptom diary can help identify your triggers. Your doctor may recommend working with a dietitian, who can help you create a personalized diet plan to reduce symptoms.
Boutros also recommends tracking the time of day when symptoms occur, which can help determine what strategies will be most effective. For example, she says, if patients recognize that symptoms are worse in the evening, they can make changes like eating dinner earlier or taking medications with dinner rather than breakfast.
Medications and Supplements
Medications and supplements used to treat LARS include:
- Fiber supplements, such as psyllium husk, to help prevent multiple bowel movements within a short time period
- Antidiarrheals, such as loperamide (Imodium) and ramosetron, which can reduce incontinence and urgency
- Laxatives to treat constipation, which can lead to “overflow” diarrhea
- Ondansetron (Zofran), a medication that’s commonly used to prevent nausea and is known to slow down bowel motility
- Perianal skincare to reduce anal skin irritation
Pelvic Floor Physical Therapy
Enemas and Transanal Irrigation
Transanal irrigation is a procedure in which you self-administer a balloon filled with warm water into the rectum, which causes the bowels to empty. This allows you to control when you have bowel movements. The process takes about 20 to 30 minutes and must be performed daily. “It needs a motivated patient,” says Boutros, “but it really does change people's quality of life.”
Sacral Nerve Stimulation
Colostomy
Finding Support
It may feel isolating trying to manage LARS on your own. “There's only so much you can talk to your friends and family about your poop habits,” says Boutros.
Your doctor can help you find a peer support group to attend. “Bringing it up to your provider and seeing what kind of resources they can connect you to is a very important step,” says Moon.
There are also online communities, such as Facebook groups, where LARS patients can connect. “The only caution would be that these are not monitored by healthcare professionals,” says Moon, “so be a little careful about any sort of medical advice that may be shared.”
The Takeaway
- Lower anterior resection syndrome (LARS) is a bowel dysfunction syndrome that commonly affects people who have had colorectal cancer surgery.
- Symptoms include increased bowel frequency and urgency, incontinence, and difficult or painful bowel movements.
- LARS can improve significantly with treatment strategies like lifestyle changes, medication, and pelvic floor therapy.
- Peer support can help you cope with the emotional impact of living with LARS.
Resources We Trust
- Cleveland Clinic: Lower Anterior Resection Syndrome
- Johns Hopkins Medicine: Low Anterior Resection Syndrome Information Guide
- Colorectal Cancer Alliance: Nutrition With Low Anterior Resection Syndrome
- Fight Colorectal Cancer: Pelvic Floor Health
- LARS Collective: Online Resources
- Nguyen TH et al. Low Anterior Resection Syndrome. Current Gastroenterology Reports. August 4, 2020.
- Low Anterior Resection Syndrome Information Guide. Johns Hopkins Medicine.
- Rectum. Cleveland Clinic. March 3, 2023.
- Giglia MD et al. Overlooked Long-Term Complications of Colorectal Surgery. Clinics in Colon and Rectal Surgery. April 2, 2019.
- Low Anterior Resection Syndrome (LARS). WashU Medicine Department of Surgery.
- Low Anterior Resection Syndrome (LARS). Cleveland Clinic. December 31, 2025.
- Bazzell A et al. Clinical Management of Bowel Dysfunction After Low Anterior Resection for Rectal Cancer. Journal of the Advanced Practitioner in Oncology. September 1, 2016.
- Rosen H et al. Management of Low Anterior Resection Syndrome (LARS) Following Resection for Rectal Cancer. Cancers. January 26, 2023.
- Low Anterior Resection Syndrome. Kaiser Permanente.
- Holte SS et al. Effect of Psyllium Husk on Low Anterior Resection Syndrome After Rectal Cancer Surgery: A Pilot Prospective Cohort Study. Frontiers in Surgery. December 9, 2025.
- Zhang R et al. Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment. Cancers. October 15, 2023.
- Solnica A et al. Nursing Recommendations for Symptom-Specific Self-Care of Low Anterior Resection Syndrome: A Systematic, Scoping Review of the Literature. Cancer Nursing. January 2, 2026.
- Popeskou SG et al. Ondansetron for Low Anterior Resection Syndrome (LARS): A Double-Blind, Placebo-Controlled, Cross-Over, Randomized Study. Annals of Surgery. February 1, 2024.
- Son GM et al. Analgesic Effect of Structured Anal Skin Care for Perianal Dermatitis After Low Anterior Resection in the Rectal Cancer Patients: Prospective, Single-Center, Open-Label, Therapeutic Confirmatory, Randomized Clinical Trial. Annals of Surgical Treatment and Research. December 8, 2022.
- Asnong A et al. The Role of Pelvic Floor Muscle Training on Low Anterior Resection Syndrome: A Multicenter Randomized Controlled Trial. Annals of Surgery. November 2022.
- Liu T et al. Therapeutic Strategies for Low Anterior Resection Syndrome: An Umbrella Review of Systematic Reviews. International Journal of Colorectal Disease. August 5, 2025.
- Yuan Y et al. The Efficacy of Retrograde and Antegrade Enemas in the Management of Low Anterior Resection Syndrome in Patients Undergoing Rectal Resection: A Systematic Review and Meta-Analysis. BMC Gastroenterology. May 23, 2025.
- Sacral Nerve Stimulation. Cleveland Clinic. September 18, 2024.
- Pires M et al. Sacral Neuromodulation for Low Anterior Resection Syndrome: Current Status—A Systematic Review and Meta-Analysis. International Journal of Colorectal Disease. July 10, 2023.
- Colostomy. Cleveland Clinic. November 4, 2024.
- Sharp G et al. Systematic Review of the Management Options Available for Low Anterior Resection Syndrome (LARS). Techniques in Coloproctology. February 4, 2025.
- Homma Y et al. Incidence of Low Anterior Resection Syndrome and Its Association With the Quality of Life in Patients With Lower Rectal Tumors. Surgery Today. August 2024.
- Løvall C et al. Patients’ Experiences of Living With Low Anterior Resection Syndrome Three to Six Months After Colorectal Cancer Surgery: A Phenomenological Study. PLoS One. July 10, 2024.
- Moon J et al. The Impact of an Interactive Online Informational and Peer Support Application (App) for Patients With Low Anterior Resection Syndrome (LARS) on Quality of Life: A Multicenter Randomized Controlled Trial. Surgical Endoscopy. January 8, 2025.

Yuying Luo, MD
Medical Reviewer
Yuying Luo, MD, is an assistant professor of medicine at Mount Sinai West and Morningside in New York City. She aims to deliver evidence-based, patient-centered, and holistic care for her patients.
Her clinical and research focus includes patients with disorders of gut-brain interaction such as irritable bowel syndrome and functional dyspepsia; patients with lower gastrointestinal motility (constipation) disorders and defecatory and anorectal disorders (such as dyssynergic defecation); and women’s gastrointestinal health.
She graduated from Harvard with a bachelor's degree in molecular and cellular biology and received her MD from the NYU Grossman School of Medicine. She completed her residency in internal medicine at the Icahn School of Medicine at Mount Sinai, where she was also chief resident. She completed her gastroenterology fellowship at Mount Sinai Hospital and was also chief fellow.

Zoe Cunniffe
Author
Zoe Cunniffeis a health journalist who specializes in chronic illness, women's health, and the doctor-patient relationship. She has written for publications such as The BMJ, Aeon, Slate, and Salon.